One thousand compounds were tested in both ferrets and h…
One thousand compounds were tested in both ferrets and humans for their ability to induce a specific response at a defined dose. All compounds were scored as either positive (produces response) or negative (does not produce response) in both species. The results of the experiment are presented below, where each cell of the 2×2 matrix is the number of compounds in thatcategory. For example, 138 of the 1000 compounds tested were negative in ferret and positive in human. Analyze and describe the ability of the ferret response assay to predict the human response over this set of compounds by determining the sensitivity specificity positive predictive value negative predictive value and overall accuracy of the ferret assay Use units of % for all parameters. Answers must be included in the box below. Please show all your work using scrap paper to perform your calculations. To receive full credit, you must upload a photo of all work performed on scrap paper to Canvas.
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15 major Pharmaceutical companies were surveyed about how they evaluate the impact of a candidate drug on the renal system. 90% of respondents stated they perform renal function testing during toxicology studies. A. Briefly explain why pharmaceutical companies would evaluate this system as a part of toxicology studies. [5pts] B. Name one established and one new biomarker correlating with drug induced kidney injury (DIKI). [5pts]
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