Exercise 28.3 Matching #2: Drugs and Their Primary Indications Instructions: Match each drug class or group with its corresponding primary indication.

(Porterfield, 2 pt) HTLV-I infection is associated with three key human diseases. List one of them. 

(Teng, 2 pt).Which one of the following viruses is associated with Kaposi’s sarcoma in humans?

Guselkumab was compared to placebo for the treatment of ulcerative colitis in a randomized double-masked controlled trial. At the end of the trial, participants who received guselkumab were 15% more likely to be in remission from their ulcerative colitis (p=0.003). What type of statistical error is the study at risk for?

The following is an excerpt from an abstract. Write the PICOS: Objective: To assess the efficacy of intranasal midazolam in children with acute seizure when compared to conventional IV benzodiazepine (BDZ). Methods: PubMed, google scholar, websites clinicaltrials.gov and the WHO-international clinical trials registry platform, were searched. Randomized controlled trials comparing intranasal midazolam against IV BDZ in the treatment of acute seizures in pediatric patients followed for at least 24 hours were included. The primary outcome was time to seizure cessation.

A preceptor asks you to look up the difference in the proportion of sustained pain freedom over 24 hours for rimegepant 75mg to ubrogepant 50mg.  Report the results as you would to a pharmacy preceptor.

Eliciting the red reflex in a newborn is a method to assess for

A randomized controlled trial is designed to compare troglitazone to placebo as adjunct therapy to insulin in patients with type 1 diabetes. The trial had a primary outcome is A1c and patients have a goal of an A1c of 7% or less. The investigators determined they needed to enroll 327 participants to achieve 80% power to detect a 0.5% decrease in A1c with a one-sided alpha level of 0.05. What is the null hypothesis for this trial?

The following figure is from a systematic review of observational studies of middle and high school students. It comparing those who used e-cigarettes to those who did not for their risk of asthma. Interpret the results of the forest plot.

A randomized controlled trial compared standard duration varenicline use of 3-months to extended-use varenicline of 6-months. The trial randomized 200 patients in each arm. Which statistical test would be most appropriate to test for the difference in baseline systolic blood pressure between groups?