A RCT compared eptinezumab (a new CGRP antagonist) to topiramate for migraine prevention using an NI margin of 0.5 monthly migraine days. The mean decrease in monthly migraine days with eptinesumab was 3.9 days and with topiramate was 4.1 days (mean difference 0.2 days; 95%CI -0.02 to 0.42). Which of the following statements is the best interpretation of the results?

Itepekimab was compared to placebo in a RCT for use in patients with moderate-to-severe atopic dermatitis (i.e. severe skin inflammation and itching). The primary outcome was changes in the Eczema Area and Severity Index (EASI) score which has a minimally clinically important difference of a change in at least 6.6 points. At week 16 in the RCT, itepekimab had a mean decrease in the EASI score of 14.2 points compared to placebo (p=0.12).

A network meta-analysis was conducted comparing the efficacy of various SSRIs for their the Hamidal Drepression Scale (HAM-D) among older adults. The results in the league table below are the standardized mean differences between each agent. What are the results for fluoxetine compared to sertraline?

A cohort study is conducted on the likelihood of developing diabetes and includes several risk factors. They use regression to account for the relationships between those risk factors. Below is a subset of their findings for the relationship with the risk factor and the development of diabetes:- A 1 kg/m2 increase in BMI leads to an OR of 1.32 for diagnosis of diabetes- Exercising for at least 2 hours per weeks leads to an OR of 0.82 for diagnosis of diabetes- Cigarette smoking leads to an OR of 1.42 for diagnosis of diabetes Which of the following statements is most accurate for the interpretation of these results?

A RCT used a sample size calculation for 90% power with a 2-sided alpha of 0.05. A sample size of 438 participants per arm was calculated assuming a 10% relative risk reduction in the primary outcome. Which of the following scenarios would require an INCREASE in sample size? (SELECT ALL THAT APPLY)

A study compares is determining the impact of daily consumption of green tea on systolic blood pressure. Among patients who began drinking green tea daily (n=23) the systolic blood pressure decreased by a mean of 5 mmHg and among patients with no dietary change (n=32) the systolic blood pressure decreased by a mean of 1 mmHg. Which of the following tests would be most appropriate to determine if the results are statistically significantly different?

An L-C circuit has an inductance of 0.596 H and a capacitance of 0.090 nF . During the current oscillations, the maximum current in the inductor is 1.35 A. What is the maximum energy stored in the capacitor at any time during the current oscillations?

A RCT compared occurrence of flares in patients with gout. The results showed febuxostat compared with allopurinol resulted in a HR of 1.07 (95%CI 1.02–1.09). Which of the following statements best describes the interpretation of these results?

The following 4 scenarios are all from double-masked RCTs. Which of the following situations would be at the highest risk for decreased internal validity due to compromised masking?

The magnetic field is uniform over each face of the box in the diagram. With 3.8 T and 9.8 T, the magnetic field at the front surface marked with a ‘?’ is given by: