In general terms, briefly indicate several ways in which Notch signaling is different from a receptor tyrosine kinase pathway. There is no need to describe each step in the pathway, focus on the main differences.

Describe the mechanistic role of SOS in the EGF signaling cascade. Be sure to discuss its biochemical activity and the impact of that activity on interacting partners. (one does not need to describe the entire pathway).

Which of the following conditions may contribute to the hyperphosphorylation of pRb?

Cytokine receptors are used by mammalian cells to communicate with their environment. Functionally, cytokine receptors operate much like tyrosine kinase receptors, with some differences. Name two differences.

Which of the following viruses can cause cancer in humans

Which is the correct order of a signaling cascade that leads to the activation of Ras?

Which of the following lines of evidence supports the conclusion that cancer cell phenotypes are recessive?

v-Raf is a virus-acquired form of the serine/threonine kinase RAF (BRAF). Which of the following best describes the molecular nature of the mutation that causes v-RAF to be constitutively active.

An increase in cyclin D activity may result from all of the following EXCEPT

Select each true statement regarding the consequence of Rb binding to E2F.