A 5-year-old girl becomes very ill after a bacterial infecti…
A 5-year-old girl becomes very ill after a bacterial infection. She was found to have toxic shock due to exposure to bacterial superantigens. Superantigens are different from regular antigens in that they stimulate many T cells. This excessive stimulation is accomplished by antigen binding outside of the normal MHC class II cleft presentation. Superantigens act by binding MHC Class II on APCs to which of the following receptors on T cells?
Read DetailsLet’s consider a small randomized clinical trial designed to…
Let’s consider a small randomized clinical trial designed to compare the response of a continuous variable between patients randomized to one of two treatments, A or B, using a permuted block design with a block size of 2. That is, for each block of two patients, one receives treatment A and the other receives treatment B, with the order chosen at random. Why do most clinical trials avoid using permuted block randomization with such small block sizes?
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