GradePack

    • Home
    • Blog
Skip to content
bg
bg
bg
bg

GradePack

The lungs consist of many small air sacs and blood vessels,…

The lungs consist of many small air sacs and blood vessels, which greatly increase surface area and improve the transfer of substances through their walls. The structures in the digestive system most similar in function to these air sacs and capillaries are the _____.

Read Details

Use the following figure to answer the next few questions.Fi…

Use the following figure to answer the next few questions.Figure 21.1 Types of DNA sequences in the human genome.The pie chart in Figure 21.1 represents the relative frequencies of the following in the human genome:Which region includes Alu elements and LI sequences?

Read Details

Normal changes that are occur in the breast during pregnancy…

Normal changes that are occur in the breast during pregnancy include:

Read Details

The van-der-Waals parameters for carbon dioxide gas are: a =…

The van-der-Waals parameters for carbon dioxide gas are: a = 3.640 bar L2/mol2 b = 4.267 x 10-2 L/mol A 2.30 Liter cylinder contains 235 g of carbon dioxide at a temperature of 240.0°C. Part a) Calculate the pressure of the gas using the ideal gas equation of state. Provide your answer in bar. Part b) Calculate the pressure of the gas using the van-der-Waals equation of state. Provide your answer in bar. Part c) Modify the van-der-Waals equation to include only repulsive interactions between the gas molecules and calculate the resulting prediction for the pressure. Provide your answer in bar. Part d) Calculate the pressure needed to compress the gas to half of its initial volume at a constant temperature using the (full) van-der-Waals equation of state. Provide your answer in bar. Solve this problem on paper, document your approach and provide intermediate results.  Report the final answers with 3 significant figures.  Scan the pages(s) and upload them for grading.

Read Details

What year is the Medicare Hospital Insurance Trust Fund expe…

What year is the Medicare Hospital Insurance Trust Fund expected to be depleted?

Read Details

What is significant about Wheatley’s writing this poem as an…

What is significant about Wheatley’s writing this poem as an enslaved African-American woman? 

Read Details

A cobblestone appearance of the conjunctiva is most likely r…

A cobblestone appearance of the conjunctiva is most likely related to:

Read Details

In which of the following periods would you expect to see an…

In which of the following periods would you expect to see an adaptive radiation?

Read Details

Phyllis Wheatley wrote poetry that pointed out the contradic…

Phyllis Wheatley wrote poetry that pointed out the contradiction between colonists demanding freedom while enslaving Black people.

Read Details

RPE65 is a major protein of unknown function found associate…

RPE65 is a major protein of unknown function found associated with the human eye that is associated with a number of different eye diseases. One hypothesis is that RPE65 is an enzyme involved in the chemical synthesis of the pigment that makes the human eye light sensitive. In a search as to which pathway intermediate RPE65 acts on, the following dissociation constants were measured (Table 1). They were compared to BSA, which stands for bovine serum albumin and is found in large concentrations in cow milk. Table 1:  Binding Constants of Various Retinoids with RPE65 and BSA in pM (10^-12 M). The numbers in brackets (  ) indicate the errors of the binding constant determination. Ligands RPE65 (pM) BSA (pM) A: all-trans-retinyl palmitate 20 (6) 2143 (790) B: 11-cis-retinyl palmitate 14224 (3006) 2310 (611) C: all-trans-retinol 1078 (144) 2316 (1216) D: 11-cis-retinol 3811 (100) 2143 (800)   Part A. 4 points What is the purpose of comparing the dissociation constants of 4 different ligands with two different proteins, RPE65 and BSA?  Part B. 5 points What is the association constant for 11-cis-retinol binding to RPE65? Part C. 5 points What is the difference in standard binding free energy between ligand A binding to RPE65 as compared to BSA. Part D. 4 points Which is the best (highest affinity) ligand for RPE65? Justify your choice. Part E. 4 points Would you say that RPE65 binding to any of the ligands is specific? Justify your answer. Part F. 10 points If you add a 10 nanomolar concentration of ligand A to a solution containing RPE65, what percent of ligand A is bound to RPE65? Part G. 10 points If you repeat the same experiment as in part F with BSA, i.e. if you add a 10 nanomolar concentration of ligand A to a solution containing BSA, what percent of ligand A is bound to BSA? Solve this problem on paper, document your approach and provide intermediate results.  Report the final answers with 3 significant figures.  Scan the pages(s) and upload them for grading. Answer all parts A to G.

Read Details

Posts pagination

Newer posts 1 … 37,415 37,416 37,417 37,418 37,419 … 98,082 Older posts

GradePack

  • Privacy Policy
  • Terms of Service
Top