Sickle cell anemia is an autosomal recessive disease caused…
Sickle cell anemia is an autosomal recessive disease caused by a mutation in the gene that encodes the hemoglobin protein. Homozygous mutations in this gene lead to the production of mutant hemoglobin protein. When only mutant hemoglobin protein is produced, red blood cells (RBCs) adopt an abnormal sickle shape and their function is impaired. On December 8, 2023 the FDA approved Casgevy to treat sickle cell anemia. Casgevy is the first medical use of the CRISPR-Cas gene-editing system. Casgevy uses CRISPR-Cas9 technology to cut a gene in the genome. What gene is targeted by the Cas9 used in Casgevy?
Read DetailsA yeast strain was exposed to a chemical mutagen. As expecte…
A yeast strain was exposed to a chemical mutagen. As expected, exposure to mutagen resulted in a DNA sequence change in an essential gene (required for survival) you examined. Yet this mutation did not result in any lethal phenotype (cause death). Which of the following answers would BEST explain this apparent discrepancy?
Read DetailsChoose the best answer from the choices below. A couple has…
Choose the best answer from the choices below. A couple has a child with cystic fibrosis. Neither parent has cystic fibrosis. This couple wants to have a second child. What is the probability that this second child will have cystic fibrosis?
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