Mandatory Question: Everyone MUST answer this question (14 pts total). Question 1:  The total number of immunoglobulin genes in humans are at 2.5 x 105, whereas the total repertoire of immunoglobulin diversity is estimated at 5 x 1013. How can there be so many Ig variants? 1a. “7 Pts” One of the key features of immunoglobulin and TCR genes is that there are multiple genes present in the genome. The accompanying Table lists a hypothetical number of variable, diversity and joining genes in humans for the heavy and c light chains. From this table, calculate heavy chain diversity, light chain diversity and total diversity.   1b. “ 7Pts” Is existence of multiple genes enough to explain all Ig diversity found in B cells. What mechanisms are in place create such diversity. What is the major mechanism of creating such diversity?

 How many grams of active ingredient are in 1 L of a 0.4% solution?

 A physician has ordered a 500 mL bag of D5NS to be infused at 80 mL/hr. How many bags will be needed in a 24-hour period?

 How many milliliters of active ingredient are in 2.5 L of a 15% solution?

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 An IV solution has a total volume of 250 mL and is being administered over 120 minutes using microdrip tubing with a drop factor of 60 gtts/mL. What is the IV flow rate in drops per minute? Round your answer to the nearest whole number, if necessary.

 How many grams of active ingredient are in 220 mL of a 12% solution? 

 There are 20 g of active ingredient in a 250 mL solution. What is the percentage strength of this solution? Round your answer to the nearest tenth of a percent, if necessary.

 A prescription order is written for 245 mg of a medication. The pharmacy stocks this medication in 35 mg tablets. How many tablets will be needed to achieve the prescribed dose?