What is the main challenge in identifying small-effect genetic variants for complex traits?

What is the primary advantage of using cattle as a model organism for studying complex traits?

Which of the following is an example of a putative QTN?

Why is linkage disequilibrium (LD) in cattle different from that in humans?

Which of the following is NOT a criterion used to select candidate genes for QTN identification in the article?

Fine-mapping QTLs typically reduces the confidence interval, leading to more precise QTL identification.

In dairy cattle, which design is most commonly used for QTL detection?

The effective population size (Ne) of cattle has increased over time, similar to human populations.

Question 2 (10 points) Show that the given differential equations is exact or not.  If its exact, solve it directly.  If its not exact, solve it by finding an appropriate integrating factor.

Phenobarbital (Luminal) 45 mg p.o. BID is ordered for a child with seizures weighing 35 lb. The recommended dosage is 6 to 8 mg/kg every 24 hr. in 2 divided doses.True or False: the dosage ordered is safe.  (Prove mathematically)