In a 1 month old with alpha thalassemia, you would expect to find:

A 25-year-old woman presents with fatigue and pallor. Her laboratory results are as follows: Hemoglobin (Hgb): 8.0 g/dL Hematocrit (Hct): 24% Reticulocyte Count: 5% RBC Count: 2.8 x 10⁶/µL Reticulocyte Maturation Factor: 2.0 (adjusted for anemia, for Hct

You are performing a differential for a patient with absolute leukocytosis and lymphocytosis. The following peripheral blood picture under the microscope should prompt you to do which of the following?

Combined with the relative reticulocyte count, which index can provide the greatest insight into activity of the bone marrow during treatment for an anemia? 

Hypersegmentation of neutrophilic nuclei is hallmark of which disorder?

A 9-year-old girl has bruising noted on the extremities and back, reportedly recurrent for one month duration. Lab results show a Hgb 7.1 g/dL, Hct 22.8%, MCV 89 fL, platelet count 63,000/µL, WBC count 19,128/µL. BM biopsy shows 100% cellularity with replacement by primitive cells with large nuclei, delicate chromatin; indistinct nucleoli with scanty cytoplasm. These cells mark for CD10 (CALLA) antigen. Which of the following is the most likely diagnosis?

A patient reports to the lab for annual blood work. The CBC shows moderate anemia, which is reported to the physician. Morphologically, the RBCs are of normal size and shape. A reticulocyte count is reflexed and reported to be 0.7%, with a RPI = 1. Which cause of anemia is suggested?

A burn patient develops leukocytosis and a “shift to the left”. Large light blue staining cytoplasmic inclusions are found near the periphery of many neutrophils.  These inclusions are probably

A 62-year-old patient presents with complaints of fatigue, pallor, and occasional shortness of breath. On examination, he has pale conjunctiva and mild glossitis. A CBC reveals the following results: Hemoglobin: 8.5 g/dL  MCV: 115 fL WBC: 3.2 x 10⁹/L  Platelets: 95 x 10⁹/L  Reflex Tests Ordered: Serum Vitamin B12: Low Serum Folate: Normal Serum Iron: Normal Bone Marrow Biopsy: Hypercellular with dysplasia in all three cell lines. Based on the clinical findings and laboratory results, which is the most likely diagnosis, and what features differentiate this diagnosis?    

Which AML subtype reacts positively with MPO and specific esterase, and shows evidence of t(8;21):