A 24-year-old male presents to his primary care physician fo…
A 24-year-old male presents to his primary care physician for evaluation of recurrent fever, night sweats, and weight loss. The patient reports that he has been experiencing these symptoms for the past several weeks. After a complete physical exam and a series of laboratory and diagnostic tests, the patient undergoes an excisional lymph node biopsy (see image). He is determined to have Stage IIB disease. Which of the following clinical findings would be an adverse prognostic factor in this patient?
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