A 24-year-old male is admitted with acute appendicitis. He develops diffuse abdominal pain, fever, and hypotension. Imaging shows free air under the diaphragm. What is the most likely complication?

A 19-year-old male presents with severe abdominal pain and hematochezia. Colonoscopy shows cobblestoning and skip lesions. What is the most likely diagnosis?

A 74-year-old female with hypertension presents with confusion and a sodium level of 118 mEq/L. She recently underwent hip surgery and has been receiving morphine. Urine is concentrated, and serum osmolality is low. What is the most likely cause of her hyponatremia?

A 60-year-old female with a recent diagnosis of breast cancer is found to have a BRCA1 mutation. What is the implication of this genetic finding?

A 63-year-old male presents with progressive fatigue, weight loss, and vague abdominal discomfort. Imaging reveals hepatosplenomegaly and lymphadenopathy. A biopsy confirms chronic lymphocytic leukemia (CLL). What cellular characteristic best explains this diagnosis?

A 22-year-old patient who weighs 62kg is admitted to hospital after taking an overdose of propranolol tablets. She admits to taking 28 propranolol 40mg tablets. The patient is prescribed intravenous glucagon and given an initial bolus of 10mg over 10 minutes. Following the bolus, she is prescribed an intravenous infusion at a dose of 50microgram/kg/hour for 60 minutes. The glucagon solution used for the infusion is prepared at a concentration of 1mg/mL. How many milligrams of the glucagon will the patient receive in total Give your answer to ONE (1) decimal place.

A nurse dissolves TWO prednisolone 5mg soluble tablets in 20mL of water.     What is the prednisolone concentration in mg/mL of the resulting solution? Give your answer to ONE (1) decimal place.

A 13-year-old patient is prescribed IV clarithromycin 500mg BD. He weighs 44kg, is 135cm tall and has a recent serum creatinine of 128 micromol/L.   The equation to calculate eGFR in paediatric patients is provided below: eGFR (mL/minute/1.73m2) = height (cm) x 40 / serum creatinine (micromol/L) The usual dose of clarithromycin is reduced by 50% if the eGFR is between 10-50 mL/minute/1.73m2 and by 75% if the eGFR is less than 10 mL/minute/1.73m2.   How many milligrams of clarithromycin should be prescribed for this patient per dose?

A 21-year-old female patient is currently prescribed citalopram 20mg tablets at a dose of 20mg once daily in the morning. She is not tolerating citalopram and a decision is made to switch her on to mirtazapine. The cross-tapering regimen is provided below:   Drug Current dose Week 1 and 2 Week 3 and 4 Week 5 and 6 Citalopram 20mg OM 10mg OM 5mg OM   Mirtazapine     15mg ON 15mg ON You prescribe the patient citalopram 10mg tablets and inform them to halve the tablets when a 5mg dose is required.   How many citalopram 10mg tablets should be prescribed to complete the cross-tapering regimen?

A 36-year-old patient is currently prescribed lithium citrate (Priadel) 520mg/5ml liquid at a dose of 15mL AT NIGHT. To improve compliance, the decision is made to switch him to lithium carbonate (Priadel) 200mg MR tablets.   How many Priadel 200mg MR tablets should the patient be prescribed for each dose?   Extract from Online BNF for lithium