The following questions refer to the discovery and function…
The following questions refer to the discovery and function of p53. a) Describe the discovery of p53 and its initial identification as a tumor suppressor. b) Explain the central role of p53 as the “Guardian of the Genome” in preventing cancer development. c) What are the types of mutations typically seen in p53 and how do they lead to cancer progression? d) Discuss the dominant-negative effect of p53 mutations in cancer.
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