ATTEMPT ANY TWO (If you answer all three, Dr. Davé will review them all and select the best two for a maximum of 6 points.) a.) Explain the sequential mechanism involved in heterochromatin formation as directed by histone methylation. (3 pts) OR b.) Providing an example of the interferon gene, describe how sequential chemical modifications on histone tails facilitate promoter activation to initiate gene transcription. (3 pts) OR c.) What is a Chromodomain? Explain the role of Chromodomain in regulating gene expression. (3 pts)

Deschenes Questions: 42-45 A prokaryotic mRNA transcribed from the E. coli araB gene has the sequence: 5’- UUUGGAUGGAGUGAAACGAUGGCGAUUGCA-3’ Two potential initiator AUG sequences are indicated in bold font.  How does the incoming ribosome and initiator tRNA-MET know where to start translating (1 pts)?

ATTEMPT ANY TWO (If you answer all three, Dr. Davé will review them all and select the best two for a maximum of 6 points.) If the Adenine (A) in the YURAC intronic sequence is lost, explain in mechanistic detail what will be its effect on RNA splicing. (3 pts) OR Describe the unique features of 5’-Cap of the Eukaryotic mRNA in chemical terms and state the importance of the 5’-CAP structure. (3 pts) OR Describe the function of TBP, TFIIB and TFIIH in PIC formation during initiation of (3 pts)

ATTEMPT ANY TWO (If you answer all three, Dr. Davé will review them all and select the best two for a maximum of 6 points.) a.) Explain (with names) four disease syndromes with chromosomal abnormalities (3 pts) OR b.) Give three features of Z-DNA and compare/contrast it with features of regular B-DNA (3 pts) OR c.) Draw a representative chromosome structure and identify the various cytogenetic features. (3 pts)

The first provision of the Nuremburg Codes states which of the following is “absolutely essential in the ethical conduct of research involving human subjects”?

Which of the following focuses on team strengths and increases a system’s potential for positive change?

Which of the following is best for the writer to see whether data are related?

In which of the following way can critical success factors be used to ensure an organization’s optimal performance?

Which of the following is the most important reason all care providers must maintain data integrity, security, and privacy of health information?

Which of the following best describes synthesis writing?