is dependent on decreasing pH.

is catalyzed by cargo-FG repeat interactions through the nuclear pore complex.

could be effective in cancer cells with unregulated export of an oncogenic protein that functions in the cytoplasm.

is only seen in cancer cells.

is conducted solely in the mitochondria.

results in growth signal receptors all being degraded.

less O2 is required for a given amount of glucose oxidized.

mitochondria are the cells ONLY way of producing ATP.

(A) Diagram how aberrant exocytosis/endocytosis homeostasis participates in altering cancer cell response to growth factors and leads to malignancy and metastasis (2 pts.) (B) Diagram and label the key organelles of a eukaryotic cell. In this diagram compare the make-up (topology) of the lumen and membrane(s) of various organelles.  What does their make-up suggest about their evolutionary origins?  From this comparison how can the various organelles be grouped? (4 pts.) (C) Indicate the three main protein trafficking mechanism and where they occur.  What organelles are connected and what proteins are trafficked by each mechanism? (3 pts.) (D) Diagram what is meant by “polarized” protein secretion. (2 pts.) (E) Early endosomes function as the sorting site of endocytosed material.  Diagram and briefly describe the four possible fates for an endocytosed molecule after reaching the early endosome in polarized cells. (4 pts.)

increasing the Na+ concentration inside the cell.