Two neurons are placed in a bath solution where pre-synaptic…
Two neurons are placed in a bath solution where pre-synaptic neuron 1 (N1) makes an excitatory chemical synapse onto post-synaptic neuron 2 (N2). A stimulating device causes action potentials to develop in N1 (the red spikes are the APs). These APs propagate down the axon of N1 and cause the release of glutamate neurotransmitter from N1 onto N2. The glutamate receptor in this scenario is the ionotropic AMPA receptor which causes an EPSP in N2. The image below shows the membrane potential traces recorded during a control experiment. Which of the following would occur if you accidentally included an antagonist of GABA receptors to the bath solution and then stimulated N1 with the brief positive current using the same electrode? (reminder that agonists of GABA receptors cause IPSPs)
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