Consider the compound Elamipretide shown here. ENTER A, B, C, D, E or NONE to complete the blanks… *** a) Identify a region that is considered POLAR [blank1] *** b) Identify a region that is considered lipophilic [blank2] *** c) Identify a region that includes that amino acid Phenylalanine [blank3] *** d) Identify a region that can ionize greater than 50% at pH 7.4 [blank4] *** e) What types of bonds present in Elamipretide would readily hydrolyze under acidic conditions? Briefly explain… [blank5]

Identify the amino acid(s) with a side chain that behaves as an ACID  at physiological pH (7.4).   (select all that apply)                 I.                                                           II.          III.  

Consider the panel of amines.  – Select the amine group or groups that is/are most likely to be hydrogen bond acceptors.

Refer to the drug shown. The statement is FALSE …. correct it in the blank. (e.g.,    incorrect = ionized; correct = unionized) 1. Drug Y is amphiprotic. [blank1]  

Consider the drug hydroxyzine (1) and its two salt forms, 2, and 3. QUESTIONS: *** a) Which form is likely the ORGANIC salt? [blank1] *** b) Which form is likely “hydroxyzine pamoate? [blank2] *** c) Are the salt forms of a drug typically MORE or LESS soluble than the neutral parent compound? Briefly explain… [blank3] *** d) Of the SALTS, which salt is more lipophilic than the other? Briefly explain. [blank4] *** e) Based on the salt forms shown, hydroxyzine can be categorized as a(n): [blank5] (e.g. acid or base)

Consider the drugs PB and AU shown here. Which drug could form a salt by reacting with NaOH?  

True/False… Vitamin D shown here has a steroidal pharmacophore.  

Consider the neurotransmitters shown below. Notice similarities and differences, then answer the questions below *** a) The pharmacophore of these three compounds is best described as: [blank1] *** b) What is the significance of the “Iso” in the isoprenaline chemical name? [blank2] *** c) What is the significance of the “NOR” in the noradrenaline chemical name? [blank3] *** d) Noradrenaline binds better to “alpha receptors” while isoprenaline binds better to “beta receptors” and Adrenaline binds equally well to both “alpha” and “beta receptors”….  Which functional group seems to be most important for the different binding to the receptors?[blank4] *** e) What is the alternative name for Adrenaline? [blank5]

Consider the neurotransmitters shown below. Notice similarities and differences, then answer the questions below *** a) The pharmacophore of these three compounds is best described as: [blank1] *** b) What is the significance of the “Iso” in the isoprenaline chemical name? [blank2] *** c) What is the significance of the “NOR” in the noradrenaline chemical name? [blank3] *** d) Noradrenaline binds better to “alpha receptors” while isoprenaline binds better to “beta receptors” and Adrenaline binds equally well to both “alpha” and “beta receptors”….  Which functional group seems to be most important for the different binding to the receptors?[blank4] *** e) What is the alternative name for Adrenaline? [blank5]

GCHEM RECALL! *** Note: if you prefer, you can answer this question on the scratch paper — if you do, please enter “see scratch paper” in blank 1*** Barium sulfate (BaSO4) is utilized in “barium swallow milkshakes” prior to taking x-rays of the digestive tract.  (note: when typing in chemical equations, don’t worry about formatting subscripts, for example BaSO4 = BaSO4 but use parenthesis as needed, for example Na3(PO4) = Na3(PO4) ) 2pt *** a) Write the balanced chemical equation describing how you would prepare BaSO4 from two aqueous solutions resulting in a BaSO4(s) precipitate.   (your answer should be in the format of reactants —> products) [blank1] 2pt *** b) Classify your reaction for blank1 (e.g. neutralization, double replacement, single replacement, etc.) and explain your choice. [blank2] 1pt *** c) Similarly, write an balanced equation for when CaCO3 (the main component in TUMS antacid) reacts with stomach acid, HCl [blank3]