You are charged with helping to take care of the patient who…
You are charged with helping to take care of the patient who is deteriorating from a glioblastoma, AKA glioblastoma multiforme (GBM) or a grade IV astrocytoma, which is the most common and aggressive type of brain cancer. It’s a fast-growing tumor that can spread within the brain and to other parts of the body (metastasis) in the median survival is only about a year after diagnosis with standard treatment. The most recent imaging of your patient shows that the tumor invaded and destroyed the posterior lobe of the pituitary gland and the most recent lab work is showing he is hypernatremic and he has hyposthenuria, where the urine has a relatively low osmolarity due to inability of the kidney to concentrate the urine normally. The attending physician submits an order to for you to start intravenous administration of the drug desmopressin (a synthetic analog of vasopressin, AKA antidiuretic hormone). Taking all this together, from the options below, which is a disease that mostly likely could have developed based on the HPI (history of present illness), recent test results, and the medication order?
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