Wilson disease is caused by mutations in the copper exporter…
Wilson disease is caused by mutations in the copper exporter ATP7B characterized by excess copper accumulation in the liver. Would you expect someone with Wilson disease to have higher or lower liver triglycerides? [1 point] What is the mechanism driving changes in liver content in Wilson disease? [3 points]
Read DetailsIn the paper we discussed in class, the authors showed that…
In the paper we discussed in class, the authors showed that loss of the copper exporter ATP7A impaired adipogenesis of 3T3-L1 preadipocytes and subsequent copper accumulation Copper accumulation leads to stabilization of what signaling molecule? [1 point] Increased activation of the above signaling pathway impairs the adipogenic lineage and instead 3T3-L1 cells differentiate toward which lineage? [1 point]
Read DetailsThere is no systemic iron export pathway and iron is only re…
There is no systemic iron export pathway and iron is only removed by bleeding, so control of iron release into circulation is critical to maintain homeostasis. What is the name of the hormone that controls iron release into circulation and how does it function? [2 points] Which extracellular signaling pathway controls production of this hormone in response to changes in systemic iron levels, infection, or pregnancy status? [2 points]
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