Spironolactone acts:

This drug may have adverse “endocrine” side effects leading to gynecomastia and galactorrhea.

This cytotoxic inorganic metal complex drug is non-phase specific and binds directly to guanine in DNA and RNA

This drug inhibits neuronal reuptake of norepinephrine and serotonin into presynaptic nerve terminals. It also blocks serotonergic, alpha adrenergic, histaminic, and muscarinic receptors and improves mood in 50-70% of patients with major depression.

The use of this drug along with methotrexate is found to enhance remission of rheumatoid arthritis.

The drug Spironolactone acts in the collecting tubules and belongs to which drug class:

Which of the following statements concerning the anti-inflammatory effect of glucocorticoids is CORRECT?

Osmotic diuretics:

This drug is an inhibitor of aldosterone and is given to avoid gynecomastia induced by Spironolactone.

Which of the following is an adverse side effect of the anti-rheumatoid drug, methotrexate?