Match the following drugs with the appropriate adverse effects below. Each answer may be used more than once or not at all:     

Resistance to clotrimazole occurs by the following mechanism:                                      1.       Point mutations in the cytochrome b gene2.       Mutations within the gene encoding for the integrase enzyme 3.       Mutations in the gene encoding for the arabinosyl transferase enzyme4.     Mutations in the gene encoding 14-α-demethylase enzyme.5.       Mutation within the gene encoding for the enzyme catalase-peroxidase

The following is correct concerning doxycycline:                1.       Binds irreversibly to 30S subunit ribosome2.       Bind to the 50S subunit ribosome3.       An example is azithromycin4.       Narrow spectrum5.       Binds reversibly to 30S subunit ribosome 

Regarding penicillins:                                                                                                              1.        Are bacteriostatic2.       Are all completely absorbed when administered orally 3.       An example is trimethoprim4.       Are largely administered topically5.       Are cell wall synthesis inhibitors

 12.    The following can be administered orally:                                                                              1.        Benzylpenicillin2.        Procaine benzylpenicillin3.       Benzathine benzylpenicillin4.        Phenoxymethylpenicillin5.        Methicillin

The following increase the half-life of a drug except:                                           1.        Diminished renal flow as result of a heart failure2.        Decreased extraction ratio as in renal disease3.        Decreased metabolism4.        Increased protein binding5.        Increased metabolism

The following drug is classified as a selective Cyclooxygenase (COX-2 inhibitor):     1.        Celecoxib2.        Tramadol3.        Morphine4.        Paracetamol5.       Diazepam

The following anticancer drug is classified as an antimetabolite:                       1.       Chlorambucil2.       Cyclophosphamide3.       Ifosfamide4.       Methotrexate5.       Melphalan

The following is classified as β-lactam antimicrobial agents:                              1.       Glycopeptides2.       Lincosamides3.       Macrolides4.        Aminoglycosides5.        Cephalosporins

The following are classified as protein synthesis inhibitors except:       1.       Aminoglycoside2.       Lincosamides3.       Macrolides4.       Tetracyclines5.       Sulphonamides