A 62-year-old patient presents with complaints of fatigue, pallor, and occasional shortness of breath. On examination, he has pale conjunctiva and mild glossitis. A CBC reveals the following results: Hemoglobin: 8.5 g/dL  MCV: 115 fL WBC: 3.2 x 10⁹/L  Platelets: 95 x 10⁹/L  Reflex Tests Ordered: Serum Vitamin B12: Low Serum Folate: Normal Serum Iron: Normal Bone Marrow Biopsy: Hypercellular with dysplasia in all three cell lines. Based on the clinical findings and laboratory results, which is the most likely diagnosis, and what features differentiate this diagnosis?    

Which AML subtype reacts positively with MPO and specific esterase, and shows evidence of t(8;21):

Hypochromic, microcytic anemia is found in which stage of iron deficiency?

Which describes the marrow of a patient with Fanconi’s anemia?

Which value is most useful to morphologically classify anemia?

A 55-year-old male consulted his physician because of weakness, lightheadedness, vertigo, and angina. The patient also complained of sores on his tongue. The physical examination revealed jaundice. The pulse rate was increased, and the spleen and liver were slightly enlarged. The tongue appeared smooth and bright red in color. Family history revealed no clues. Neurological exam revealed quickening of reflex responses. Patient history indicated a total gastrectomy five years earlier for stomach cancer and intermittent heart problems that had not required surgery. The physician ordered the following tests: TEST                    RESULTSWBC                    3.1 × 109/LRBC                      2.45 × 1012/LHGB                     10.5 gm/dLHCT                     29.0%MCV                    118 fl MCH                    42.8 pg MCHC                 36.2 gm/dLRDW                    15.7PLT                       83 × 109/L Differential: Segs     49%Bands   6%Lymphs 30%Mono   8%Eos        5%Basos    2% Peripheral blood: macro-ovalocytes What is (are) the most appropriate reflex test(s)?

This painful disorder is characterized by marked itching, peeling, red skin. Immunophenotypic studies of cells from the peripheral blood identify malignant T lymphocytes lacking CD5 and CD7.

The erythrocytic morphology in megaloblastosis is best characterized by:

The erythrocytic morphology in megaloblastosis is best characterized by:

All of the following mutations are commonly detected in cases of Esstential thrombocythemia and Primary myelofibrosis, except: