(2pts TOTAL) Many intraocular lenses (IOL, commonly known as…
(2pts TOTAL) Many intraocular lenses (IOL, commonly known as contacts) are made up of polymethylmethacrelate (PMMA). Although advancements have been made, there is still evidence that PMMA is not entirely biologically inert. To address this one group has looked at the effects of heparin surface modification (HSM) to enhance biocompatibility of PMMA lenses. Aqueous flare is defined as the breakdown of the blood-aqueous-barrier which causes blood borne proteins and cells to leak into the space inside the eye between the iris and the cornea’s innermost surface, the endothelium. Answer the following questions below. (0.4pts) Explain the significance of the following plot and what you have been told about aqueous flare in regard to potential immune response. *What happens, why, and how VERY BRIEFLY* (0.4pts) The following plot interrogates fibroblast adhesion to the IOL over time. An asterisk (*) represents a statistical difference. Describe the results in this figure AND their biological significance. *What happens, why, and how (type of tissue) VERY BRIEFLY* (0.4pts) The following plot interrogates foreign-body giant cell adhesion to the IOL over time. An asterisk (*) represents a statistical difference. Describe the results, why this happens, and their biological significance. (0.4pts) Based on the results in these figures, would you recommend continued production of HSM IOLs? Justify your answer. (0.4pts) Assume you decided to add foreign cells to your HSM polymer implant. Describe how the body would respond to this combinatorial (cells + synthetic biomaterial) implant. Specifically describe the sequence of events in terms of the types of inflammation and types of tissue formation.
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