A mouse model of Fragile X Syndrome exhibits the repetitive behavior of excessive marble burying. In class, we discussed how scientists alleviated this symptom in the mouse model using the CRISPR-Cas9 system. The figure below shows some of the data we discussed. First: Label the bars in the above bar graph by matching the letter that corresponds with each bar to the genotype to which that bar refers. Bar A refers to [Wildtypecontrolmice] Bar B referes to [WTCas9] Bar C refers to [FMR1knockoutmice] Bar D refers to [FRM1Cas9] Second: Select the best answer to the question below from the dropdown menu. How did the researchers deliver the CRISPR-Cas9 components to the mice? [2nd]

Consider the process of RNA Interference. Match the description on the left with the best term on the right. Each term will only be used once.

Consider CRISPR-Cas9 technology. Match the description on the left with the best term on the right. Each term will only be used once.

A modifier screen is a type of forward genetics. The main difference between a forward genetic screen and a modifier screens is:

To get from correlation to cause, scientists must do reverse-genetic experiments. Cao et al. wondered if increased antimicrobial peptide (AMP) expression in dnr-1 mutants caused neurodegeneration.  How did they answer this question?

List four general side effects of radiation therapy.

Bonus Question: This question will not count against you. Answering the question correctly will award you an additional 5 points to your raw score. You may use scratch paper to draw a dihybrid cross if needed.  If the genotypes of these two parents is AaBb x AaBb, what ratio would represent the expected PHENOTYPIC outcomes?

In Drosophila, the sex of an individual is determined by

Would this trait be X-linked or autosomal?  

Using genetic mapping and the crossover frequencies provided, determine the order of these genes.