A 35-year-old woman underwent multiple surgeries after a car accident. Her surgeon prescribed 10 mg of Vicodin (acetaminophen+ hydrocodone) taken daily for her postoperative pain. The treatment provided adequate analgesia (pain relief). The accident led to a recurrence of her major depressive disorder, for which she renewed her use of anti-depressant fluoxetine (Prozac) at 20 mg/day. She was unaware that hydrocodone is an inactive prodrug and the substrate for CYP450-2D6 enzyme that transforms it to hydromorphone – an active form of this drug and the actual analgesic. She was also unaware that Fluoxetine is a strong CYP450-2D6 inhibitor. As result of this drug interaction she experienced:

Prolonged administration of a drug often requires to increase its dose to obtain the same effect. This is due to a well-known phenomenon called:

In the dose–response curve, a decrease in potency is indicated by a shift

During the process of behavioral drug tolerance, after repeated, frequent use of a drug in the same environment:

The nurse clarifies that the immune system failure theory states that:

The older adult has a better chance of adjusting to continued aging in positive ways if he or she:

What is a great way to keep the older adult involved in the community?

In chapter 10 of your text is the photo of a rose.  What fragrant compound is mentioned in its caption?

When providing teaching to the older adult, it is important for the nurse to:

An older adult may begin to lose some hearing acuity. You know that: