Describe the mechanism of action of dolutegravir.                    

Regarding drug interactions with penicillins:                                                                      1.       Administration with erythromycin inhibits penicillins’ effects2.       Administration with streptomycin has synergistic effect with penicillins3.       Administration with salicylates inhibits penicillins’ effects4.       Administration with probenecid enhances penicillins’ effects5.       Administration with tetracycline enhances penicillins’ effects 

The following drug is associated with reduction in bone mineral density:                     AcyclovirEmtricitabineTenofovirEntecavirEthambutol 

Resistance to clotrimazole occurs by the following mechanism:                                    1.       Point mutations in the cytochrome b gene2.       Mutations within the gene encoding for the integrase enzyme 3.       Mutations in the gene encoding for the arabinosyl transferase enzyme4.      Mutations in the gene encoding 14-α-demethylase enzyme.5.       Mutation within the gene encoding for the enzyme catalase-peroxidase 

The following antibacterials do not inhibit liver enzymes:                                               1.       Amikacin2.       Neomycin3.       Ciprofloxacin4.       Chloramphenicol5.       Ofloxacin  

The following anaesthetic agent can produce dissociative anaesthesia:                      1.        Propofol2.        Ketamine3.        Etomidate4.        Midazolam5.        Mivacurium 

Match the following drugs with their correct class below. You may use an option more than once or not at all.  

The primary site of biotransformation of amide local anaesthetic take place in the:1.        Stomach2.        Kidney3.        Blood plasma4.        Lungs5.        Liver 

Describe the mechanism of action of amphotericin B.                                                        

An antagonist is a substance that:                                                                                               1.       Decreases the action of endogenous ligand2.       Produces no effect3.       Binds to identical receptor macromolecules as the agonist 4.       Increases the action of endogenous ligand5.       Has weak affinity for the target receptor