Guselkumab was compared to placebo for the treatment of ulce…
Guselkumab was compared to placebo for the treatment of ulcerative colitis in a randomized double-masked controlled trial. At the end of the trial, participants who received guselkumab were 15% more likely to be in remission from their ulcerative colitis (p=0.003). What type of statistical error is the study at risk for?
Read DetailsThe following is an excerpt from an abstract. Write the PICO…
The following is an excerpt from an abstract. Write the PICOS: Objective: To assess the efficacy of intranasal midazolam in children with acute seizure when compared to conventional IV benzodiazepine (BDZ). Methods: PubMed, google scholar, websites clinicaltrials.gov and the WHO-international clinical trials registry platform, were searched. Randomized controlled trials comparing intranasal midazolam against IV BDZ in the treatment of acute seizures in pediatric patients followed for at least 24 hours were included. The primary outcome was time to seizure cessation.
Read DetailsA randomized controlled trial is designed to compare troglit…
A randomized controlled trial is designed to compare troglitazone to placebo as adjunct therapy to insulin in patients with type 1 diabetes. The trial had a primary outcome is A1c and patients have a goal of an A1c of 7% or less. The investigators determined they needed to enroll 327 participants to achieve 80% power to detect a 0.5% decrease in A1c with a one-sided alpha level of 0.05. What is the null hypothesis for this trial?
Read Details