Simvastatin should not be used concurrently with the following drug, due to increased risk of myopathy:                                                                                EmtricitabineLopinavir/ritonavirAcyclovirLamivudineEntercavir

The dose-limiting side effect of bleomycin is:                                AnaphylaxisAlopeciaPulmonary toxicityBlister formationHyperkeratosis

Resistance to emtricitabine occurs by the following mechanism:                1.   Mutations in the plasmodial cytochrome b gene2.   Mutations on the mycobacteria catalase-peroxidase enzyme3.   Mutations in the viral neuraminidase enzyme 4.   Mutations on the viral reverse transcriptase enzyme5.   Mutations in the fungal glucan synthase enzyme

Pyrazinamide is associated with the following drug interactions:                                             1.   Decreases hepatic metabolism of warfarin; dosage adjustment is necessary2.   Decreases the effectiveness of oral contraceptives by enhancing their metabolism 3.   Decreases urate clearance, thus dosage adjustment of antigout agents necessary4.   Decreases metabolism of alcohol, concomitant use is best avoided5.   Decreases the blood levels of nevirapine, concurrent use is best avoided

The following drug is associated with haemorrhagic cystitis:              BleomycinMethotrexateCyclophosphamideRituximabVincristine

Resistance to emtricitabine occurs by the following mechanism:               1.   Mutations in the plasmodial cytochrome b gene2.   Mutations on the enzyme catalase-peroxidase3.   Mutations in the viral neuraminidase enzyme 4.   Mutations on the viral reverse transcriptase enzyme5.   Mutations in the fungal glucan synthase enzyme

The following is a therapeutic use of topiramate except:                                                  1.        Generalised tonic-clonic seizures2.        Focal seizures3.        Lennox-Gastaut syndrome4.        Myocardial infarct5.        Prophylaxis for migraines

The following drug is used for the treatment of herpes simplex virus (HSV):        1.        Abacavir2.        Tenofovir3.        Aciclovir4.        Efavirenz5.        Lopinavir

Match the following drugs to their most correct adverse effects. Each answer may be used more than once or not at all.

The following are indications of metronidazole EXCEPT:                                      1.        Amoebiasis2.        Giardiasis3.        Trichomoniasis4.        Fusobacterium5.        Leishmaniasis