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For each of the following mutations, indicate whether the mu…

For each of the following mutations, indicate whether the mutation would likely promote (P) or inhibit (I) apoptosis in cells harboring the mutation(s). Your answer should be a four-letter string consisting of “P” and “I” only (e.g., PPPI). A mutation in the pro-apoptotic effector Bcl2 family proteins Bax and Bak that prevents their association with the outer mitochondrial membrane. A mutation in the BIR domain of the IAP protein DIAP1 that prevents binding to either caspases or anti-IAP proteins. A mutation in the anti-IAP protein Reaper that prevents its binding to IAP proteins. A mutation in the CARD domain of caspase-9 that prevents its binding to Apaf1.

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Complete the following sentences by filling in the blanks wi…

Complete the following sentences by filling in the blanks with the most appropriate term from the list provided. Note that not all terms will be used. apoptosome eat me phosphatidylserine cytochrome c initiator inhibitor extrapolar executioner condensation fragmentation Apaf1 In the intrinsic pathway of apoptosis, a protein called [response1]  is released from the mitochondria into the cytosol and binds to the adaptor protein [response2], causing it to oligomerize into a wheel-like assembly called an [response3], which then recruits [response4] caspase-9 proteins. Next, [response5] caspases lead to the execution phase that results in DNA [response6] and corpse engulfment.

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