A 9-year-old girl has bruising noted on the extremities and back, reportedly recurrent for one month duration. Lab results show a Hgb 7.1 g/dL, Hct 22.8%, MCV 89 fL, platelet count 63,000/µL, WBC count 19,128/µL. BM biopsy shows 100% cellularity with replacement by primitive cells with large nuclei, delicate chromatin; indistinct nucleoli with scanty cytoplasm. These cells mark for CD10 (CALLA) antigen. Which of the following is the most likely diagnosis?

Hypochromic, microcytic anemia is found in which stage of iron deficiency?

A patient’s hemoglobin electrophoresis on cellulose acetate shows a prominent band in the position of Hemoglobin S. However, the sickle solubility test is negative (image, middle). What is the most appropriate next step to confirm the identity of the hemoglobin variant?    

What test could provide the most definitive diagnosis differential between β-thalassemia minor and iron deficiency?

Which describes the marrow of a patient with Fanconi’s anemia?

Which AML subtype reacts positively with MPO and specific esterase, and shows evidence of t(8;21):

Which value is most useful to morphologically classify anemia?

A burn patient develops leukocytosis and a “shift to the left”. Large light blue staining cytoplasmic inclusions are found near the periphery of many neutrophils.  These inclusions are probably

Hemoglobin electrophoresis can be used to detect an abnormal hemoglobin. Findings can be confirmed and more accurately quantitated using which high resolution methodologies? 

Patients with sickle cell anemia treated with hydroxyurea have fewer episodes of sickle cell crisis because which of the following is true?