Which of the following is NOT one of the top three causes of death in the United States?

Part1: Consider the structure of the drug NICOTINE and the pKa table shown here.  Drug HA BH+ Nicotine  — N1=3.12 N2=8.02 *** a) Explain the pKa values for N1 and N2. [blank1] (e.g., the pKa for N1 is greater/less than pKa for N2 because…) *** b) At what pH would nicotine be sufficiently protonated to have a total +2 charge? [blank2] (e.g. pH = ##) Part 2: Nicotine (in nicotine gum) is sometimes flavored with artificial sweeteners such as acesulfame, an acidic compound shown here: *** c) The acidic group in acesulfame is a sulfonamide. Which point(s) on the molecule (a-f) include the sulfonamide functional group? [blank3] (e.g. a to b or b to f…) *** d) Assuming nicotine is completely ionized (+2, see b above)…If nicotine and acesulfame reacted to form a salt, what would be the ratio of nicotine to acesulfame? [blank4] (e.g. 2:3 or 2 to 3) Considering either functional group N1 or N2 in nicotine, use the Henderson-Hasselbalch equation to determine the molar ratio and % IONIZED, %UNIONIZED for Nicotine at pH 7.4  Possibly helpful equations:   pH = pKa + log(A-)/(HA)    -or-     pH = pKa + log(B)/(BH+) *** e) Please specify N1 or N2 and then your percentages: [blank5] (e.g. N1: %I = ##.#; %UI = ##.#)

GCHEM RECALL! Barium sulfate (BaSO4) is utilized in “barium swallow milkshakes” prior to taking x-rays of the digestive tract.  (note: when typing in chemical equations, don’t worry about formatting subscripts, for example BaSO4 = BaSO4 but use parenthesis as needed, for example Na3(PO4) = Na3(PO4) ) 2pt *** a) Write the balanced chemical equation describing how you would prepare BaSO4 from two aqueous solutions resulting in a BaSO4(s) precipitate.   (your answer should be in the format of reactants —> products) [blank1] 2pt *** b) Classify your reaction for blank1 (e.g. neutralization, double replacement, single replacement, etc.) and explain your choice. [blank2] 1pt *** c) Write an balanced equation for when CaCO3 (the main component in TUMS antacid) reacts with stomach acid, HCl [blank3]

What specific set of medical staff approved actions may a respiratory therapist follow independently, based on assessment results?

Consider the neurotransmitters shown below. Notice similarities and differences, then answer the questions below *** a) The pharmacophore of these three compounds is best described as: [blank1] *** b) What is the significance of the “Iso” in the isoprenaline chemical name? [blank2] *** c) What is the significance of the “NOR” in the noradrenaline chemical name? [blank3] *** d) If Noradrenaline binds better to “alpha receptors” while isoprenaline binds better to “beta receptors” and Adrenaline binds equally well to both “alpha” and “beta receptors”….              Suggest a STRUCTURE BASED explanation for these differences in selectivity. [blank4]

The drugs Irinotecan, hydrocortisone, and haloperidol have very different pharmacophores. As such, they will likely exhibit ______ biological and/or pharmacological activity.

Consider the structure of Vitamin A shown here. Label the statements as either TRUE or FALSE…

Consider the panel of amines. Match the amine with its appropriate chemical classification / description:

A drug classified as a weak unionized base would form a salt with which of the following? (if more than one answer is correct, select all that apply)

Honor Code Statement: “The work on this exam is my own and I pledge to not use any outside resources, devices or people to help me.  I pledge that I will not cheat or assist anyone else in cheating”.  Proverbs 10:9 — Whoever walks in integrity walks securely, but whoever takes crooked paths will be found out. Prayer: Philippians 4:6–7 — Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.