A 40-year-old male has been prescribed Ondansetron suppositories. What is the suppository base in this product?

Mr A is prescribed by his GP sublingual glyceryl trinitrate tablets for his angina symptoms. Considering the physiology of the buccal cavity explain why the sublingual area is suitable for systemic drug delivery and outline the advantages of the sublingual route.         (5 Marks)

A 42- year-old man would like you to recommend something for the headaches that he has been experiencing recently. They present in a band-like distribution with bilateral pain across his forehead and around the back of the head.  The headache is often accompanied by neck pain.  He is under moderate stress after starting a new job working in an office and he is worried that the headaches could be something serious. They usually occur in the evening and have been occurring once or twice weekly since starting his new job.   There are no other associated symptoms and the patient takes no regular medication.  a. Outline what condition they are presenting with and what the cause is likely to be. (2 Marks)  b. Suggest an appropriate treatment or management option for the condition. (2 Marks)  c. Give associated advice on how to manage the patient’s symptoms. This may include advice on how to use a product(s) you have suggested.     (1 Mark)

Which of the following structures is a SSRI?  

Controlled release dosage forms have several advantages over standard release preparations. Which of the following advantages is NOT an advantage of controlled release formulations?

Which unit found within the structure of naloxone is thought to be responsible for its antagonist activity?  

A consultant is thinking of prescribing bromocriptine to a 70-year-old man. Which of the following statements relating to bromocriptine is CORRECT?

Bradykinesia has made drug treatment necessary in a 60-year-old man with Parkinson’s disease. The plan is to initiate levodopa. Which of the following statements would NOT be appropriate to advise the patient with regards to levodopa therapy?

A 25-year-old man with idiopathic generalized epilepsy with generalized tonic-clonic seizures, continues to have breakthrough seizures despite being on maximally tolerated doses of lamotrigine. Sodium valproate is added to his treatment regimen. Which of the following effects may result from interaction between these drugs?

Mrs AB is a 56-year-old patient who has a history of epilepsy. She has been poorly controlled recently and her neurologist has initiated her on phenytoin. She was initially prescribed a dose of 300mg daily, however her dose has recently been increased to 350mg daily. Shortly following this dose increase she began to experience symptoms of phenytoin toxicity. Explain why small dose increments with phenytoin can result in toxicity? (5 Marks)