Controlled release dosage forms have several advantages over standard release preparations. Which of the following advantages is NOT an advantage of controlled release formulations?

Which unit found within the structure of naloxone is thought to be responsible for its antagonist activity?  

A consultant is thinking of prescribing bromocriptine to a 70-year-old man. Which of the following statements relating to bromocriptine is CORRECT?

Bradykinesia has made drug treatment necessary in a 60-year-old man with Parkinson’s disease. The plan is to initiate levodopa. Which of the following statements would NOT be appropriate to advise the patient with regards to levodopa therapy?

A 25-year-old man with idiopathic generalized epilepsy with generalized tonic-clonic seizures, continues to have breakthrough seizures despite being on maximally tolerated doses of lamotrigine. Sodium valproate is added to his treatment regimen. Which of the following effects may result from interaction between these drugs?

Mrs AB is a 56-year-old patient who has a history of epilepsy. She has been poorly controlled recently and her neurologist has initiated her on phenytoin. She was initially prescribed a dose of 300mg daily, however her dose has recently been increased to 350mg daily. Shortly following this dose increase she began to experience symptoms of phenytoin toxicity. Explain why small dose increments with phenytoin can result in toxicity? (5 Marks)

Section A   50 compulsory MCQs from across the module PHA333  (Total Marks 50) 

In the ventral tegmental area, morphine is known to act on opiate (mu) receptors located on which of the following?

A psychiatrist wishes to prescribe lithium for a patient with bipolar disorder. Which statement concerning the use of lithium in the treatment of bipolar disorder is CORRECT?

Which of the following checks is NOT recommended at least annually for people with bipolar disorder?