A solution of a drug (101.51 ppm) and internal standard (206.12 ppm) are injected onto a gas chromatograph. The peak area of the drug is determined to be 12541, and the peak area of the internal standard is 17889. What is the relative response factor (RRF)?
Read DetailsA 200 mg dose of a drug was given IV to a patient and a blood sample was taken shortly afterwards. The initial concentration of the drug in the plasma was measured as 560 μg/mL. Calculate the apparent volume of distribution (Vd) in litres.
Read DetailsThe first-generation sulfonylurea drug chlorpropamide has a half-life of 25-60 hours and a duration of glycaemic effect of 24-72 h. The structurally related analogue, tolbutamide, has a much shorter duration of action, around 6-24 h. a. With reference to the structures of the two compounds, and drug metabolism, suggest why chlorpropamide displays longer-lasting effects than tolbutamide. (3 marks) b. Clinical signs of hypoglycaemia developed in a 3-year-old boy 24 hours after he had mistakenly eaten some of the pretty blue-coloured chlorpropamide tablets, thinking they were sweets. Given that chlorpropamide is an acidic drug with a pKa of ~5.2, suggest an approach to treat the patient through enhanced elimination of the drug, with rationale. (2 marks)
Read DetailsPJ, a 60-year-old woman, has just been rushed to the Emergency Department with a chief complaint of crushing chest pain that keeps radiating to her lower jaw, left shoulder and arm. Initial management of AJ’s presenting condition is likely to include all the following, EXCEPT:
Read DetailsA 68-year-old patient is prescribed dabigatran capsules for the prophylaxis of VTE following a total knee replacement. How many dabigatran 110 mg capsules will you need to supply to cover the full course? Extract from Online BNF
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