Let’s consider a small randomized clinical trial designed to…
Let’s consider a small randomized clinical trial designed to compare the response of a continuous variable between patients randomized to one of two treatments, A or B, using a permuted block design with a block size of 2. That is, for each block of two patients, one receives treatment A and the other receives treatment B, with the order chosen at random. Why do most clinical trials avoid using permuted block randomization with such small block sizes?
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