Two managers from Appliance King were talking to Uri, their district manager, about Hannah, the unpopular store manager. Vivian, the assistant manager, said, “I believe I speak for other managers and employees when I say that Hannah acts like she knows it all. We all feel that Hannah does not listen to any of us because she always thinks her way is right and does not want to consider any other opinion.” Hannah is an example of a geocentric manager.

The general environment, or macroenvironment, includes six forces: economic, technological, sociocultural, demographic, political-legal, and international.

Betsy, the vice president of sales for an international organization, believes that employees in her foreign offices understand best how to handle the personnel and practices in their offices. So when the corporate HR manager approached Betsy about reprimanding Francois, a native Parisian who is the Paris office manager, for not doing things according to corporate policy, Betsy backed Francois and said, “I believe that the home office should leave Francois alone because he best understands the local culture.” Betsy is a(n) ________ manager.

_______ are regulatory agencies, such as the SEC (Securities and Exchange Commission), that establish ground rules under which organizations may operate.

To focus on improving company customer service this year, the CEO of a home goods manufacturing company outlined a list of stakeholders to concentrate on: distributors, local communities, and special-interest groups. These three groups are

You are tasked to evaluate an antihypertensive drug for its oral bioavailability. Which physicochemical parameters are important to determine if a drug is feasible for oral administration? List and briefly describe optimal ranges for these parameters. Then evaluate the following structure and the provided information from SwissADME to determine if this structure has beneficial ADME properties for oral administration. Structure of antihypertensive drug Physicochemical properties Formula C17H18N2O6 Molecular weight 346.33 g/mol Num. heavy atoms 25 Num. arom. heavy atoms 6 Fraction Csp3 0.29 Num. rotatable bonds 6 Num. H-bond acceptors 6 Num. H-bond donors 1 Molar Refractivity 94.52 TPSA 110.45 Ų Log Po/w (XLOGP3) 2.20 Log S (ESOL) -3.15 Solubility 2.42e-01 mg/ml ; 7.00e-04 mol/l Class Soluble P-gp substrate No CYP3A4 inhibitor No Provide as much information as possible.

You are tasked to analyze a tablet formulation of a pharmaceutical drug using LC-MS. Explain in detail how this analytical method works (both LC and MS), how a sample containing multiple compounds can be analyzed, what the advantages of LC-MS over other analytical techniques are, and how you would validate (i.e. describing the validation parameters) a LC-MS method. Provide as much detail as possible and feel free to draw chromatograms and MS spectra to illustrate the interpretation of results.

Which of the following distinguish biopharmaceutical agents from small molecular weight drugs?

Describe the mechanism of action of local anesthetics such as procaine (structure shown) or lidocaine. Identify important structure-activity elements. Why is the degree of ionization an important physicochemical parameter for the activity of local anesthetics? What kind of amino acid residues are essential in the active center of the target for activity of the local anesthetic to be effective? Structure of local anesthetic procaine

Which of the following are advantages of solid phase extraction compared to liquid-liquid extraction?