According to the International Council for Harmonisation (ICH) guidelines for stability study of New Chemical Entity, what is the minimum period of stability data required at the time of dossier submission under accelerated conditions?

Techceuticals developed a suspension dosage form of a new chemical entity and the product is subjected to accelerated stability studies. The stability analyst reported the following data after 12 weeks of the study. Which of the following would you consider as “significant change” in the product performance?

What specific tissue subtype of cartilage is located between the bones in a symphysis?

Problem 1: Single- and Multiple-Choice Questions (22 points)   This problem comprises 10 single- and multiple-choice questions. The number of points that you can earn in a question range from one to three points and is always shown at the end of the question. In single-choice questions, you get the full number of points if you select the correct answer. Otherwise, you get zero points. In multiple-choice questions, you get one point for each correct answer and minus one point for each incorrect answer. You cannot earn less than zero points in a question. If you do not answer a question, you will get zero points for the question. a) Multiple-choice question: Assume that there is a convertible bond with a face value of $1,000. It can be converted into 250 shares. The current share price is . What is the absolute and the relative conversion premium? Are investors willing to convert their bonds into shares in this situation? (3 points)

Problem 6: Miscellaneous topics including debt prospectuses, IPO activity and underpricing, risk-return relation, capital budgeting, and capital structure (22 points) d) Charline, a colleague of yours, must evaluate several mutually exclusive investment projects that require different amounts of initial investment. Charline computes the internal rate of return (IRR) of all projects and then recommends the project with the highest IRR to be implemented. More specifically, she argues that, by picking the project with the highest IRR, the firm’s value will be maximized. There are two subquestions about this setting: (4 points in total) Do you agree with her assessment? Explain your answer. (2 points) Independent of your answer to the first subquestion, what would be necessary conditions for being able to use the IRR to maximize firm value when selecting between mutually exclusive investment projects? Explain your answer. (2 points)

Problem 1: Single- and Multiple-Choice Questions (22 points)   i) Single-choice question: Omega Tech Ltd. recently had its initial public offering. The offer price of Omega Tech Ltd. was $12 per share. At the end of the first trading day, Omega Tech Ltd. traded at a price of $18 per share. What is the underpricing of Omega Tech Ltd.’s IPO? (2 points)

Problem 5 – Excel: Weighted Average Cost of Capital and Capital Structure (9 points) Download the attached Excel file “Problem_5_Template.xslx” and answer the questions stated in the Excel file: Problem_5_Template.xlsx When you have completed your solutions, please upload the Excel file with your solutions to your e-exam using the name “StudentID_Problem_5.xslx” (e.g., “123456789_Problem_5.xlsx”). When you want to upload an updated version of your solutions, please add a version tag (e.g., “_v2”) at the end of the file name (e.g., “123456789_Problem_5_v2.xlsx”). This problem consists of three parts. Parts a), b), and c) yield 2, 4, and 3 points, respectively.

Problem 1: Single- and Multiple-Choice Questions (22 points)   h) Multiple-choice question: This question is about the internal rate of return (IRR) method in capital budgeting. Please select all correct statements. (2 points)

Problem 4 – Excel: Capital Budgeting (15 points) Download the attached Excel file “Problem_4_Template.xslx” and answer the questions stated in the Excel file: Problem_4_Template.xlsx When you have completed your solutions, please upload the Excel file with your solutions to your e-exam using the name “StudentID_Problem_4.xslx” (e.g., “123456789_Problem_4.xlsx”). When you want to upload an updated version of your solutions, please add a version tag (e.g., “_v2”) at the end of the file name (e.g., “123456789_Problem_4_v2.xlsx”). This problem consists of four parts. Parts a) , b), c), and d) yield 3, 5 , 3, and 4 points, respectively.

Neutrophils are especially important in: