Two-component histidine kinase regulatory system directly se…
Two-component histidine kinase regulatory system directly senses the presence of daptomycin outside of cells and responds by activating expression of MprF that adds lysines to phospholipids. This addition negatively charges the membrane; hence, it repels negatively charged daptomycin.
Read DetailsColistin is a last-reserve polymyxin antibiotic prescribed a…
Colistin is a last-reserve polymyxin antibiotic prescribed against multi-drug resistant bacterial infections that rapidly develop resistance to antibiotics. In fact, bacteria carrying mcr family genes are already resistant to colistin. According to the WHO antibiotic classification, colistin is
Read DetailsTwo-component histidine kinase regulatory system directly se…
Two-component histidine kinase regulatory system directly senses the presence of daptomycin outside of cells and responds by activating expression of MprF that adds lysines to phospholipids. This addition negatively charges the membrane; hence, it repels negatively charged daptomycin.
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