Using a reaction coordinate diagram (G vs. reaction plot), (A) indicate the effect of an enzyme catalyst on DGrxn, DG‡, (3 pts.) and (B) the relative Gs of the substrate (S) and product (P) for a reaction that will occur spontaneously.  This includes indicating the DDG‡, the G of S‡, and the G of ES‡. (3 pts.) (C) Which of these parameters above determine the rate (kinetics) and which determines the direction (thermodynamics) of a chemical reaction? (3 pts.) (D) Circle each of the following effects that are brought about by any enzyme catalyzing the simple reaction S -> P? (2 pts.) (a) Decreased Keq; (b) Increased Keq; (c) Decreased DG‡; (d) More negative DG˚’, (e) Increase k2. (E) Diagram two of the four main types of catalytic mechanisms discussed in class and that are exemplified in the mechanism of serine protease catalysis of the cleavage of a peptide bond. (4 pts.)

Use a substitution to find the indefinite integral: ∫5xx2+34 dx{“version”:”1.1″,”math”:”∫5xx2+34 dx”}

have all been designed prior to determining the PGP structure.

Because oxygen transport across a membrane is energetically unfavorable.

Evaluate the definite integral: ∫047×2-8x+3 dx{“version”:”1.1″,”math”:”∫047×2-8x+3 dx”}

do not seem to enhance anticancer drug efficacy.

Questions 1-5For the cartoon representation of a protein structure above it is composed of:

Match the structure to the appropriate letter

PSC-833 activates P-glycoprotein.

Because oxygen can dissolve in water and leak in via water channels.