RAG-1 and RAG-2 enzymes are expressed in almost all nucleated cells to rearrange the TCR and BCR variable region genes.

Which cell types can become a plasma cell?

Which gene segment is located within the α-chain locus and is consequently deleted and inactivated once the α gene rearranges it’s gene segments?

Once expression of RAG-1 and RAG-2 genes are turned on, expression is never turned off.

Imagine you’re a doctor and you discover your infant, recently born patient has thrush. You order genetic sequencing and find that the RAG-1 gene doesn’t produce a functional enzyme.  From what you have learned in this class and with this information at hand, you can conclude that:

The V-region genes segments of a TCR undergo gene rearrangement

MHC I binding site is formed from the (α) alpha 1 and (β) beta 1 subunits.

Which of the following subsets of B-cells is the most abundant?

Which of the following subsets of B-cells is the most abundant?

Which of the following catalyzes the release of the CLIP from an MHC II molecules so that antigen peptides can be loaded?