The following is the mechanism of resistance to amphotericin B:                                   1.       Mutations in the gene encoding α- sterol demethylase enzyme                                                                                                                                             2.       Impaired ergosterol binding 3.       Accumulation of stepwise mutations of the protease gene                                                   4.       Altered fungal deoxyribonucleic acid (DNA) polymerase.                                                                                5.       Multiple-layered thick cell wall, which may limit drug entry  

State three clinical conditions that require the use of prophylactic antimicrobials. 

Describe the mechanism of action of cycloguanil                                                                      

The following statement is true regarding prazosin:                                                          1.       It competes with norepinephrine at the α1-adrenoreceptors2.       Causes an increase in vascular smooth muscle tone 3.       Competes for the same binding site with β2-adrenoreceptors4.       Results in reduced blood pressure5.       Is an antihypertensive drug  

Paracetamol may be used in the following condition:                                                      1.        Diarrhoea2.        Pyrexia3.        Vomiting4.        Bleeding5,        Motion sickness 

Match the correct terms with their relevant descriptions.

The following antibacterials are metabolised in the liver:                                               1.          Gentamycin2.          Erythromycin3.          Tetracycline4.          Cloxacillin5.          Kanamycin   

State two complications of antimicrobial therapy.

Match the following drugs with the most corresponding adverse effect below. Each answer may be used more than once or not at all.        

Amoebiasis therapy includes the following:                                                                      1.        Tenofovir2.        Niacin3.        Metronidazole4.        Isoniazid5.        Lamivudine