Suppose a laboratory expands its acceptable limits for quality-control results from 0 ± 2s to 0 ± 2.5s. What is the potential negative aspect of this change?

How many points in the above Levey-Jennings chart are beyond 2SD away from the mean?    

Which of the following best describes the analysis of samples to establish reference intervals for a new laboratory method?

Which of the following are true about quality control pools?   1. Commercially bought lyophilized material is preferred material due to its stability   2. Clarified frozen or liquid pools typically have lower SD.   3. Pool matrix does not have to match test samples.   4. Liquid pools may experience greater instability errors associated with shipping batches of a lot to a customer.  

Cyclic variations refer to changes in concentration of analytes that occur in a predictable manner. ______ variation is a phrase used to describe reproducible variation that occurs during the course of a single day, and ______ variation is a phrase used to describe reproducible variation that occurs over a period of greater than one day. 

Utilizing 95% confidence limits for quality-control materials, one would expect how many valid quality-control test results to fall outside the established limits?

Your laboratory manager is comparing two different methods to analyze  D plasma concentrations. He uses a NIST reference standard that has a certified concentration of 35.00 mg/dL. Using the following data calculate the bias for both methods.  Using an F-test determine if the precision is equal for the two methods (critical p < 0.05, report your calculated two-tailed p value).  Which method is more precise?  Which method is more accurate? Reference material used = 35.00 mg/dL   Method A Method B Analyte D (mg/dL) Analyte D (mg/dL) 34.6 36.4 33.4 36.6 34.3 36.1 35.4 36.1 33.2 36.2 35.9 35.9 37.6 36.3 30.5 37.3 33.4 35.3 34.8 35.4 31.6 37.4 34.6 36.2 36.8 36.4 33.3 35.1   36.5   35.7   35.9   36.4    

An abrupt and sustained change of control values in one direction is known as a ______, and a gradual change of control values in one direction is known as a ______. 

Typically, serum or plasma glucose levels are measured on venous blood samples. Suppose an arterial sample is used to measure the glucose level for a particular patient. Why should the use of an arterial sample for this patient’s glucose be noted on the patient’s laboratory report?

Convert the patient’s serum glucose concentration from question 46 to mmol/L (GFW for glucose = 180.16 Da)