Which of the following statements is TRUE regarding the DNA fingerprinting gel below? Image description: A DNA fingerprinting gel of PCR results for a single STR. Lane 1 is the allele ladder. Lane 2 is the crime scene sample. Lanes 3-6 are suspects A-D.

Shown below is a fragment of a DNA sequence and its translated protein. Which of the options results in a NONSENSE mutation of this sequence? The base mutations and any subsequent changes in the amino acid that it codes for are identified in red. Image description: The normal DNA sequence is TAT CAT CCT AAG GTA … The normal PROTEIN sequence is Tyr His Pro Lys Val….

Deficiency in this can cause achromatrichia

Deficiencies of this can cause microcytic, hypochromic anemia

Prompt 2: Genetic Mechanism – Lyonization and Mosaicism 1) Discuss how random X-chromosome inactivation (lyonization) produces mosaicism in Kell antigen expression in female carriers of the McLeod phenotype. (4 points) 2) Proper writing style (2 points)

Deficiency of this can cause black tongue disease

A patient with prior anti-Jka history presents with anemia after transfusion. Current antibody screen is negative. What explains this?

A Kell antibody reacts poorly in LISS but strongly in PEG-enhanced IAT. What does this suggest?

Prompt 1: Molecular Basis – XK and Kell Interaction 1) Describe the role of the XK gene and its interaction with the Kell glycoprotein in the McLeod phenotype. 2) Proper writing style (2 points)

Which of the following muscles CANNOT be palpated on clinical examination?