A 60 year old patient complaining of dull aching pain in his…
A 60 year old patient complaining of dull aching pain in his left knee comes into the office. Initially, his pain was aggravated by movement, but seemed to improve when he rested. Now it seems to be hurting all of the time and is also making a creaking noise when he stands up. Which of the following is the first biochemical pathogenic change you would expect with this pathology?
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