A 74-year old female was admitted to the hospital 4 days ago…
A 74-year old female was admitted to the hospital 4 days ago for an elective procedure and has been ventilated since surgery. Today the medical team notes the patient has a fever, decreased oxygenation, and is requiring frequent suctioning of purulent respiratory secretions. A CXR reveals a RLL infiltrate, and a diagnosis of ventilator-associated pneumonia is made. No recent antibiotic use or hospitalizations. VS: 101.5˚F, HR 106, RR 30, BP 112/66; LABs: BUN 24, SCr 2.2, WBC 14.2 Hospital antibiogram reveals the following susceptibility rates to P. aeruginosa: Cefepime: 86% Meropenem: 96% Ceftazidime: 89% Piperacillin/tazobactam: 93% Ciprofloxacin: 84% Tobramycin: 92% Amikacin: 95% Hospital antibiogram reveals the following in regards to S. aureus: Methicillin susceptible: 75% of S. aureus isolates Methicillin-resistance: 25% of S. aureus isolates You are consulted on an empiric antibiotic regimen. After speaking with the nurse to ensure appropriate cultures have been sent, which of the following is the best recommendation?
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