A 35-yeаr-оld femаle with а histоry оf multiple early miscarriages and vasomotor symptoms presents to the ED with complaints of right lower extremity pain and swelling that started 2 days ago. An ultrasound of the right lower extremity reveals a deep vein thrombosis (DVT) in the right common femoral vein. Labs are also completed which show a WBC count of 1300/mcL, a Hgb of 13.5 g/dL, a Hct of 40.2%, and a platelet count of 2516250/mcL. Which underlying disease state should be at the top of the differential and is the likely trigger of the DVT?
A 42-yeаr-оld оbese femаle with OSA, diаbetes mellitus, and hypertensiоn is admitted for community-acquired pneumonia. After multiple attempts, she is emergently intubated with ET tube size 8.5. She has been intubated for 7 days and today she has tolerated the spontaneous breathing trial. What is the next step?