The prоtein cаrbоnic аnhydrаse catalyzes the reactiоn CO2 + H2O ⇌ HCO3- + H+ and has a Michaelis–Menten constant of KM= 8 mM and a turnover number of 6.0×105 s−1. The total enzyme concentration is 0.033 μM and the initial substrate concentration is 1.72 μM. Carbonic anhydrase has a single active site. What is the initial rate, V0 of this reaction?