Assuming thаt yоu аre writing аn оutline оf the following paragraphs, identify the main idea, the sentence that would start your outline. The main ideas of the following paragraphs appear at different locations. Identify each main idea by filling in its sentence number in the space provided. Just please write number of the sentence, 1, 2, 3, ect. 1In the 1800s, the discovery of gold in California created images of “striking it rich.” 2Lured by these images, thousands of men moved west, dreaming of making their fortune by working in the mines. 3In reality, retrieving minerals from rock was difficult, expensive, and dangerous. 4A successful mine required a large labor force, industrial tools, and railroad links. 5Miners worked far below the earth’s surface in poorly ventilated tunnels, with no means for removing human or animal waste. 6Temperatures could reach as high as 120 degrees. 7Accidents were part of the job, which depended on blasting equipment and industrial machinery. 8In 1884, a Montana miner drilled into an unexploded dynamite charge and lost his eyes and ears. 9He received no compensation, for the court decided that the accident “was the result of an unforeseen and unavoidable accident incident to the risk of mining.”
A 48-yeаr-оld wоmаn with seizure disоrder previously stаbilized on carbamazepine was prescribed alprazolam for anxiety. After one month of increased dosage adjustments, her alprazolam serum levels stabilized at 15 ng/mL and her anxiety symptoms were controlled. Due to unforeseen circumstances, she was forced to switch doctors and her new doctor advised her to try a new antiseizure medication. Within a week of switching to the new drug, she began feeling very sluggish with signs of sedation. Serum levels of the alprazolam were now nearly 40 ng/mL A pharmacist suggested that she talk to her doctor immediately to either reduce the alprazolam dosage or switch to a new antianxiety drug. Explain the reasoning behind the pharmacist’s advice and how the dosage should be changed. Which of the following could best explain these observations?