You have determined your protein target to be in the cytosol of the cell, which one of these groups would make a better beginning structure for design?                                  

The association of a nonpolar ligand with a hydrophobic pocket in a protein is predominantly driven by the hydrophobic effect. This effect is primarily:

What general term is used to describe large biological therapeutically relevant molecules?

Studying the binding site for your drug in an enzyme, you determine that the binding region has a potential location to accommodate a hydroxyl group on your drug. One isozyme “alpha” possesses a tyrosine in this location. However, the alternative isozyme “beta” (the one you don’t want to target) possesses a phenylalanine. Will this impact your drug’s selectivity?

Explain the relationship between a formal charge like the +1 charge on a nitrogen atom with four substituents attached to it and the partial charge on that same nitrogen? Multiple entries can be selected as correct.

Consider the binding interactions involving the functional groups at the specified positions of the following chemical messenger.  Which atom could serve as a hydrogen bond donor (HBD)?         

Chapter 8 Which of the following statements correctly defines premium and beneficiary?

Chapter 3 Which of the following best captures the full set of functions that work together in the legal system?

Chapter 5 Which of the following best describes secondary prevention?

Chapter 8 What is adverse selection in health insurance markets?