A 45-year-old patient presents with a family history of here…
A 45-year-old patient presents with a family history of hereditary breast and ovarian cancer syndrome (HBOC). The oncologist wants to test the patient for pathogenic variants specifically in BRCA1, BRCA2, PALB2, CHEK2, and ATM — a panel of five well-established cancer predisposition genes. Cost efficiency and fast turnaround are priorities, as hundreds of samples will be processed per month. Which NGS application is most appropriate for this use case? A) Whole Genome Sequencing B) Whole Exome Sequencing C) Targeted Re-Sequencing D) Amplicon Sequencing
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